Unit 10 - Concept of Human Growth and Development
Concept of Human Growth & Development (Very Important)
- Anthropologist have always been interested in variations in human species with respect to socio cultural elements, biological and also geographical dimensions
- Growth and development during different phases of live cycle like prenatal development ,infancy ,childhood ,adolescence and senescence is of the prime concern for physical anthropologist to study individual populations or in co-relation with others
- Growth is an progressive development of an individual or an body part from its earlier stage to maturity. It is mainly studied as a quantitative increase in the size of the body or its parts it is included within the larger term development
- Growth is part of development → Growth is the Quantitative Development
- Cellular process responsible for growth can be
- Hyperplasia - when cells gets multiple, no. of cell increasing as a result of cell division involving replication of DNA leading to formation of functional identical cells
- Hypertrophy - When the size of cell is getting increase due to increase in its functional units particularly proteins
- Accretion - increase in the intercellular substances of both organic and inorganic nature, Distance between cells increase. Proteins and lipids are organic substance present b/n the cells. Inorganic is minerals
- Development → it refers to progressional changes of both qualitative and quantitative nature were undifferentiated immature cells(pluripotent steam cells are getting transformed through differentiation into different types of cells which are specialised
- The quantitative elements of development is growth only but the qualitative changes can include functional maturity and come differentiation
- Growth does not continue through out the live and generally stops after attaining maturity were as development is progressive and continues throughout the life. Later the term development was extended to include social maturity as well as behavioural changes. GOSS who elaborated the qualitative and quantitative elements of development
Principles of Growth and Development (Can be studied from Physical Notes)
Chronological and Biological Age
- Chronological age is the age of an individual as the no. of ages after the birth. i.e the actual no. of yrs a person have lived in years, months, days etc
- Biological age on the other hand represents the biological status of maturity referring to how old a person seems to be. it is an individual’s development based on biomarkers at molecular, cellular or tissue levels
- Biological age is also termed as physiological age. It is governed by genetic factors/hereditary factors/lifestyle and the geographical conditions of the habitat. A person can be having 50 as the chronological age but physiologically the body can be matching with 40 yrs. of the chronological age
Somatotyping*** ( Can be Studied from Physical Notes)
Introduction
- Somatotype-term was coined by American physicist Sheldon
- Somatotype is a quantified expression and scientific description of the present morphological conformation or physique of a person.
- And the process of defining, appraising and explaining the somatotype is somatotyping
- Somatotypical studies have contributed in better understanding of diversity of human builds can be applied to specific diseases and disorders like austrioporisis, scientific studying of ageing, diet plan and nutritional requirements for individuals, exercise programs for athletes to achieve their full potential
- Along with genetic factors environmental factors, nutrition also defines the somatotype.
Viola’s Method of Somatotyping
- He was an Italian physician
- Proposed classification of somatotypes based on physique through photoscopic studies and latter used some anthropometric measurements
- he differentiated 4 different types of somatotypes
- Longitype
- Brachitype
- Normotype
- Mixed
Longitype - longer limbs relative to the trunk volume, larger thorax relative to abdomen and large transverse diameter relative to anterior and posterior
Brachitype - is opposite of longitype short limbs related to trunk, less transverse diameter relative to anterior posterior and shorter thorax relative to abdomen. Massive and robust bodies
Normotype - a proportional size of limbs and truck, thorax and abdomen and transverse with the anterior posterior diameters (they are b/w Longitypes and Brachitypes)
Mixed - disproportional body size ,non uniformity physique, the above indices fail to reach upto a conclusion ,not very much common
Sheldon’s Method of Somatotyping
Introduction to Sheldons Method
- Book-‘Varieties of human physique’
- Sheldon defined somatotype as quantification of 3 primary components determining the morphological characters of an individual expressed as a series of 3 numerals
- 1st is endomorphy, 2nd is mesomorph, 3rd is ectomorph
- Each component of the physique is assessed individually on a 7 point scale with one as the least expression(minimum), 4 as the moderate and 7 as the hight /full expression(maximum)
- The rating of each component determines the somatotype which is expressed by the 3 numerals for which the sum is minimum 9 or maximally 12
- The conceptual approach of Sheldon’s method is based on the premise that continuous variations occur in the distribution of physique and thus a variation is related to differential contribution of 3 specific components i.e endo ,meso or ecto morphs.
- Sheldon studied somatotyping by dividing the body into different components like
- Head, Neck and face
- Upper (Thoracic Trunk)and lower trunk (Abdominal Trunk)
- Arms ,Shoulders and Hands
- Legs and Feet
3 Extreme Somatotypes Recognised by Sheldon
Maximum individuals are a mixed of these 3 somatotypes so the somatotype rating cannot be that much absolute
Criticism of Sheldons Method
- Sheldon’s concept of somatotype was based on white men of America that too of limited age group so it was criticised for being less representative
- Sheldon stated that 1 to 7 should be the range of somatotype rating which is not elaborative also unnecessary and unjustified restrictions of total of the components b/n 9 to 12 was of no practical application. Impact on environment of human physique was ignored
- Muscular growth and fatty deposits were not explained specifically to the most prominent muscles like triceps, traf muscle etc
Heath and Carter Method
- Theoretically A combined approach of anthropometry and photocopy was used for estimation of somatotype but in practice heat and cater method is primarily anthropometric in nature as over emphasis on photocopy is time consuming, costly and not very much efficient
- The Method developed against the response for Sheldon’s Method
- Heat and Carter criticised the Sheldon’s method for accommodating a narrower range of rating ,Arbitrarily for 7 point scale and also by eliminating the unjustified sum of components b/n 9 to 12
- Under this method data was collected for somatotype rating based on Height Weight ratios HWR ,Heat and cater studied both male and Female, Somatotype
- The anthropometric measurement used by heat and cater are more objective and in the direction to standardised somatotypes and is way more efficient than focusing on photocopy
- The Somatotype components and dimensions used in this are different from Sheldon’s Method
- Advantages of heat and cater method are related to its objectivity, scientific measurements applicable to both males and females and more focus is on studying the present somatotype of an individual
Methods for Studying Growth
Two prominent methods used to study the growth
Longitudinal Method
- The same subject or group of subject is studied and measured repeatedly year after year
- Here individual rates of growth and timings of specific development can be easily analysed through the data collected
- Both the aspects can be studied like
- the individuals rate of growth
- the timings of specific development events
- Data related to growth on an individual from birth to the maturity may take up to 20 years to completed with the help of this method
- So, the principal drawback of comprehensive longitudinal study is time taking and relatively small no. of individual /subjects can be studied. also, it is very costly and dependent upon the continuous corporation of the subject as well as the enthusiasm of researcher
- It is thus essential that the highest levels of accuracy to be maintained in collecting and recording the data so that maximum results can be achieved
Cross - Sectional Method
- Here the subjects are studied only once in a way that subjects of the different ages are studied at a particular time like some at early infancy, some at early childhood, some at adolescence and some adult individuals became a part of the sample
- Cross sectional method provides a general description of age-related growth changes. the biggest advantage is growth studies can be completed within the shorter period of time
- In a comparative survey of children in different populations more focus is on the average outcomes i.e the mean and the variations in growth patterns b/n different children’s
- The biggest shortcoming of this method – is individuals’ growth and development on year-to-year basis cannot be deciphered
- To overcome the shortcomings of these two methods sequential study methods can be adopted combining the two approaches in a way that individuals from the cross-sectional samples are tested more than once and the result is analysed to understand the differences and similarities. This method seems to provide more realistic assessment than cross sectional/longitudinal methods
Patterns of Human Growth & Growth Curve
Distance & Velocity Curve
Measure of an individual taken at specific intervals and plotted against time can provide graph of progress for total amount of growth achieved
Distance Curve
Call grand which measurements are plotted against Time related to actual height of individual is call Distance Curve
It tells us things like
- height achieved for particular age is reflected
- how far child has reached towards adulthood
Distance Curve represnets amount of growth achieved at given moment or at successive time periods
Velocity Curve
Veocity curve represents variation in rate of growth with time is velocity curve. It is not defining actual height of an individual at specific age. What is defining rate of growth with time
Conclusion
British natural Scientist & mathematical biologist, Sir Darcy Thompson, in his book on growth and form explained concepts of distance and velocity curve.
He considered distance curve as “continuous succession of varying magnitude”
He defined velocity curve as rate of change of height with time and called “rate of cahnge of varying velocities”
Phases of Growth Curve
- Rapid Growth during Infancy and Childhood
- Steady and COnstant growth during Middle Childhood
- Rapud Growth during adolescence
- very slow growth as Individual appraoches adulthood
Types of Growth Curve based on Body Systems
General Curve
It describes growth of body as a whole and most of body systems, respiratory digestive, urinary and circulatory system, general car which distance covered and graphs that is
- Rapid Growth - INfancy and Very Early Childhood
- Steady and Constatn Growth - Middle Childhood
- Increase in Growth - Late Childhood
- Rapid Growth - Adolescence
- Slow and Eventual Succession of Growth - In Attainment of Adulthood
Neural Curve
Characterise growth of brain, nervous system, parts of skull and even eyes, nervous tissues, experience, rapid growth in early postnatal life and greater than 95% of total increment in size of brain is attained by age of seven years
Seven year of each. Tissues shows steady gain with slightly extra growth in adolescence.
Reproductive Curve
illustrates growth & pattern of primary & secondary sexual characteristics in males and females including growth of
- Ovaries and Uterus - Primary in Females
- Testes and Seminal Vesicel - Primary in Male
- Develeopment of Breasts - Secondary in Female
- Development of Larynx & Moustache - Secondary in Female
- Growth of Pubic Hair in both Male and Female
These tissue shows
slight growth in infancy
latent period during childhood
rapid growth in maturation during adolescence
Lymphoid Curve
It is Development Curve of Lymphatic System ( Lymph Nodes etc)
X Axis - Size Attained in % of Full Maturity in Post Natal Growth
Y Axis - Years
Lymphatic system including thymus tonsils, spleen and lymph nodes acts as a secondary circulatory system for tissue fluid is helping in development of immune response
Lymph Node curve demonstrates rapid growth, until early adolescent years, even more than 100% capacity, later it declines most probably as a result of activities of sex hormones during puberty
Stages of Human Growt
Introduction
Human Lufe Cytle starts with Fetilisation of Sperm and Egg, thus forming Zygote. then the embryonic and pre natal grwoth and development followed by birth and post natal development
Fertilisation
Fusion of Male and Female Gamets
Pre Natal Stage
- Begins with Conception
- Involves Fomration of Zygote / Embryo
- There are Stages in Pre Natal Stage
- Cells of Embryo starts dividing
- Embryo moves from Fallopian tube towards womb
- 3rd & 4th Week
- Embryo is attached with Uterus (womb) wall by 3rd ot 4th week of pregnancy
- 5th Week
- By 5th week division of Brain, Spinal Cord and Heart occurs
- Within this week
- Hear Starts Beating
- Heart becomes Cearly visible in Ultrasound
- 6th Week
- Heart
- Starts Pumping embryos own blood to his her own brain and body parts
- all 4 chambers of heart are present
- By End of this phase 1 Million heart beats have occurred
- 6 Week Embryo measures less than an Inch but still formation of arms and legs have started
- Here, Movement of Hands, Neck and Hiccups begin
- Heart is Nearly Fully Formed
- Girls have ovaries and boys have testes
- After 10 weeks developing human called foetus or unborn offspring
- Kidneys begin to produce and release urine
- Fingers and toes are fully formed and free
- Around 17th week, blood cell formations starts in the form of bone marrow
- Foetus starts to store energy in form of fats
- By 18th week formation of breathing passage is complete
- By 22nd week sense of hearing begins to dunction
- Foetus starts responding to sounds
- Between 20/23 weeks - rapid eye movement begins
- By end of 24th week > 30 million heartbeats have occured
- By 26th week sudden and loud noises may trigger response in developing foetus like it may increase body movement, heart rate
- By 29th week, pupils of eye react to light
- By 37th week foetus has a firm hand grip
- Heart has beaten > 50 million times by now
- around 38 weeks - weight of foetus > 6 pound measuring around roughly 19 niches for head to head at birth new born baby typically weighs between 6 to 8 pounds
- and heigh is around
Embryonic Stage - Conception to 8th Week of Pregnancy
Early Foetal Stage - 9th to 24th Week of Preganncy
Late Foetal Stage - 24th week of pregnancy to birth
Birth
Post Natal Development
Introduction
28 Days after birth, marks the growth and development of newly born in extra urine environment
Babies maintain a temperature within a very narrow liit
inadequate growth and development during prenatal period, disposes newborn to vulnerability specially for duration of first 28 days after birth and is pioneering factor contributing to high neo natal fatality
Phases of Post Natal Growth
Infancy / Infanthood ( After Birth 4 Weeks / 1 Month / 28 Days )
- It is the period during which nursing takes places ,typically lasting for 3 to 4 years of the age ,getting started after 28 days of the birth
- A normal healthy baby doubles its’ birth weight in the 1st 6 months and triples within a year, during this period there is a great expansion of head and the chest. Thus permitting development of heart, lungs and brain the most vital organs for survival
- The bones which are relatively soft at birth begin to harden with the process of ossification and deposition of calcium
- Calcification of posterior and anterior fontanels begin during this period
- Brain weight increases rapidly during infancy and by the end of 2nd year the brain has already reached 75% of its adult weight. Human brain grows more rapidly during infancy then any other tissue organ of the body
- The gradual attainment of control over head ,upper trunk and upper extremities is allied with accomplishment of sitting posture and proficiency in walking skills during infant hood
- The fatal posture of inverted position will be converted into holding the chin up within 1st two months of the birth and child is able to hold the chest up within two to three months of the birth
- Sits when supported in the 1st 4 months
- Sits w/o support in the 1st 6 to 7 months
- Stands w/o the support in the 1st 9 months
- Crawls in the 1st 10 months
- Walks if supported in 10 to 11 months
- Stands alone w/o support in 11 to 12 months
- Walks alone w/o any support in 12 to 14 months
- Emergence of milk teeth allows the infants to switch from breast feeding to eating appropriate required food
- Deciduous (milk) teeth emerge one month earlier in boys w.r.t girls and in all other aspects of physical growth and maturation girls are on an average of ahead of boys
Childhood - Early, Middle & Late
Early Childhood → 4 to 6 Years
- The rate of growth slows downs, dentition is immature
- Digestive system is small and not fully developed so specially prepared food is required in this stage. The neurological development along with motor skills are being developed in this phase
- Leaning abilities became faster for both skills as well as sociocultural commands and elements like bowing the head Infront of a religious place
cultural elements like adoption of language by comprehending the words is one of the significant development in early childhood
Middle Childhood → 6 to 8/9 Years
- This Stage of human growth and development. Is suppose to be most stable one w/o much changes observable changes in body height and weight
- Neurological, Psychological & Motor Skills continue to develop. The physical growth is proceeded towards 2 direction’s mainly
The Walking Pattern / Locomotion starts matching with the adults and replacement of milk teeth with permanent teeth is almost complete with the exception of second molar
Late Childhood → 9 to 11/12 Years
- Also termed as Pre Pubertal Stage
- Sexual dimorphism is emerged in this stage
- It is included by sex hormone, linear growth of the body will take place, sexual dimorphism can be witnessed i.e different looks for boys and girls
- Children will start getting better writing and reading skills/speech skills and these are signs of a dependent child becoming independent for day to day activities
Adolescence / Puberty
- The pubertal stages or the adolescent experienced the changes at a faster rate as compared to any other stage. This can be considered starting with onset of puberty when sex hormones are getting produced and is the physical transformation of a child towards adolescent and adulthood
- No. of biological changes take place during adolescent
- like sexual maturation
- increase in height and weight
- completion of skeletal growth with increase in skeletal mass
- changes in body composition wrt hormones
- protein deposition and fatty deposits
- Onset of puberty is generally 2 years earlier in girls than boys
- Average Age for girls is 11.5 to 13.5 yrs
- Average Age for boys it is 13 to 15 years
- Secondary Sexual Characteristics are expressed in both boys and girls like breast dev
- Girls - onset of menstruation (menarche-beginning of menstruation, menopause-end of menstruation)
- Girls & Boys - growth of body hair
- Boys - genital development in boys etc
- Case Study 1 : A.M Tripathi in his study of age of menarche of girls of various Indian state found that lowest age is their in girls of
- Delhi 11.2
- followed by Calcutta 12.2 to 12.7 yrs
- UP 12.8 to 13.3 years
- highest age of menarche was found in Gujarat, nearly 14.5 to 14.8 yrs
- Case Study 2 : In a study by Kant Et Al it was found that puberty appears to set in early among the Indian boys but full maturation seems to take longer time than the boys of western countries
They studied boys in central part of India. Within india the avg age of development of puberty in boys is nearly 14 yrs but is found late in tribal boys
- So the onset of puberty in both boys and girls and age of menarche in girls is not only governed by biological or physiological factors but also influenced by multiple other factors like-environmental and climatic factors ,socio economic status ,nutritional status . the upbringing environment stress ,intoxication ,pollution etc
Adulthood
- Adulthood and maturity is the time of peak physical maturity, starts getting achieved after the completion of teen ages ,full physical strength of the body is achieved in late 20’s and early 30’s. Attainment of adult stature, sexual maturation are indications of transitions from adolescence to adulthood . increase in the height stops as the long bones of the body like femur lose their capability to increase in length
- Most significant child bearing age ,fully mature immune system so there is a resistance to pathological influences
- The most striking feature is this resistance to pathological influences only as a stability, a homeostasis (stable condition ,constant internal env.) is achieved
- Maturity or adulthood is having one of the most significant activity related to cellular functioning. Full strength of the bones getting achieved and healthy sperms and eggs for procreation
Ageing & Senescence
Background
- Senescence : the condition or process of deterioration with age
- Biological Basis of Senescence : Divisional Maturity of Cells is reached and Achieved
- Ageing : Ageing is the process of becoming older
Introduction
- Also Termed as Declining Stage or Negative Growth Stage.
- Senescence Includes all those manifestations in structure and function of various organs of the body which decline or deteriorate during later periods of life
- Ageing → In Humans takes form of morphological and functional impacts as a progressive and irreversible change.
- Senescence & Ageing Leads to Gradual Decline in
Body Physiology, Metabolism and Activities of Individual →
All the Individuals follow the same human cycle of Birth, Growth, Reproductive Maturity, Senescence and Death
Three Theories of Senescence
Various Theories have been Proposed related to ageing and senescence which can be classified in Three Broad Categories
Summary
Cellular Theories
Background
- Ageing due to Intra Cellular Process
- Errors in Biochemistry of cells
Theories
Theory of Hayflick Limit - Leonard Hayflick
Running Notes
- Lungs - Fibroblasts - Divide - But Division is Limited - i.e Division is not Fully Functional throughout Life
- Hence he got an Idea that like Lung Cells → all Cells in the Body have a Divisin Limit
- As Age of Individual Increases - Cell Division Capacity of a Person (will reach a Particular Limit) & at a Point of time
- Division of Cell = Multiplication of DNA content
- Full Division Capacity will be Reached (Hayflick Limit)
- When Hayflick Limit is Reached Cells will not be able to divide the Nucleus and hence Cell will not Replace with New Cells and this will lead to Ageing
Dictation
Hayflick Reported that Fibrblastas of Human Lungs divide like Other Cells of the Body but their Division is Limited like the Same way various cells of the Body will have a capacity to divide for a Limited Number of Times which is achived at a Specified Age
Senescene and Ageing is the Result of Loss of Cell Functioning due to “its capacity to divide further is lost”.
When cells reach their maximum division point there will not be further division of cells as they cannot divide the Nucleus & Genetic Material
This Maxium Capacity of Division in Cell is Hayflick Limit
So after certain age & after acheiving a fixed number of divisions
- cells will not divide further
- dead cells will not be replaced by new cells
- events of ageing and senescene will occur
Theroy of Free Radical Reaction - Becker & Smith
Free Radical
They are continuosly produced in the body during metabolic reaction and if they are not neutralised they damage the cells
Running Notes
- FR produced contunuosly in cell
- will lead to cell damage → Leads to Death
- Neutralised by Anti Oxidants
- Presets the Ageing
- Will not allow damage to cells before its Hayflick Limit
- Here FR of O2 is talked about here. This casues ageing and damage of the cells
- Reactions
- FR O + Enzyme → Super Oxide Radicals
- Super Oxide Radicals + H2O → Hydroperoxil Radical
- (HO2) Hydroperoxil Radical (HO2)+ Free Unsaturated Lipds → Lipofuscin
Dictation
Free Radical of Oxygen are getting continuosly produced in the cells leading to damage and death of cells. as the free radicals of oxygen can be transformed easily into super oxide radicals by various enzymatic activities.
Whent this super oxide radical gets combined with water, a Highly Reactive Radical of Hydroperoxyl HO2 is getting formed
HO2 / Hydroperoxyl → will primarily combine with Free Unsaturated Lipids circulating in the cells to form ageing pigment called Lipofuscin
How will this Lead to Death ?
The Free Radicals & Lipfuscin will block the cellular Transport i.e Influx of Nutrients inside the cell and outflux of Toxins, outside the cell
This will Lead to Cell Senescene and Cell Death
Theory of DNA Errors - Hart & Setlove
Errors in DNA Replication are continuosly rectified through proof reading mainly through activity of Enzyme DNA Polymarase 1.
If the Errors of replication remain undetected, it can lead to Mutations i.e healthy DNA will not be Multiplied Further & continuos accumulation of DNA Errors will impair the cell function leading to senescene and death of the cell
Theory of Missing Factors - Dr M S Kanugo
Running Notes
- He is a Famous GerontologistT from India
- Non Functional Genes of Adulthood - Yes Problem
- Non Functional Genes of Young Age - No Problem
Dictation
In the Words of Dr Kanugo,
- Ageing is not due to Malfunctioning of Specific Genes of Childhood or Adolescence
- but due to non functioning of Genes Responsible for maintaining adulthood and later stages
- This Non Functioning could be due to
- Internal - Endogenus Factors
- Mutation
- External - Exogenus Factors
- Stress, Pollution, Nutrition, Intoxication
- Futher Studies Highlighted that : Reproductive Phase of Life of Individuals deplets certain genes/factors responsible for maintaining adulthood.
- These Missing Factors Accelarate Ageings and Senescene
Extra Cellular Theories
Background
- Ageing due to Extra Cellular Events
- Not Dysfucntioning of Cellular Machinery
- Reason is outside the cell
Theories
Immunological Theories - Burnet & Walford
Running Notes
- Important for functioning of Immunological System
- Spleen
- Lymph Nodes
- Bone Marrow
- Thymus Gland
- With time their
- Efficiency Decreases
- Degeneration Takes Place
- Leads to Ageing & Senescence
Dictation
Various Parts of the Immune Response of the body like Spleen, Lymph Nodes, Bone Marrow, Thymus etc continuously loose their efficiency after attainment of adulthood
Efficiency of Thymus Gland is the most significant one and its degeneration and decreased efficiency is contributing towards ageing of the Animal Kingdom (Humans)
Certain Genetic Changes or Mutation can also Trigger Auto Immune Response and hence leading to faster process of ageing and senescence
Collagen Theory - Group of Members
Running Notes
Structure
Three Helix
Forms Super Helix
This Super Helix dominated by Non Covalent Bonds
Process
Less Stable : Will Lead to Opening of Helix
Opening → Division of Cells
With Ageing - Non Covalent Bonds Stabilise and Transform into Covalent Bonds
Collagen Not Divde
Non Healthy Intracellular Activities
Under Nourishment of Cells
Collagen
- Collagen is the Most Abundant Protein Present in Animals
- Present in Skeletal System and Intracellular Spaces
Bonds
- Covalent Bond - formed by Sharing of Electrons - More Stable
- Non Covalent Bond - formed by Co Ordinate Bonds - Less Stable
Dictation
Collagen Protein in Animals is made up of 3 different Poly Peptide Chains forming a Super Helix supported by Non Covalent Bonds.
As Age Advances these Polypeptide chains are stabilised by covalent binds and because of this transformation.
This Transformation doesn't allow a :
Healthy Intracellular Environment and
Cellular Transport is Obstructed
leading to
Accumulation of Toxins in the Cells
& Undernourishment of Cells
Causing Senescence and Death
Modern Theories of Senescence
These are Based on Multiple Scientific Research
Background
- Mixed Approach
- There can be Multiple Reasons which can be Intra Cellular, Extra Cellular & Blend of Intra & Extra Cellular
Theories
Programmed Ageing Theory
Running Notes
- It is Pre Programmed in Cells, that after a Particular Stage, Age and Division of Cells, the Cell will stop functioning
- Chromosomes 1 & 21 - Have this Programming
- When Cell Forms it is Pre Programmed like a Biological Clock
Dictation
Theory Supports the Idea that Pattern of Ageing's and Senescence is Pre Programmed & Pre Determined & is an Inborn Mechanism confined to Chromosome 1 & Chromosome 21
Hence it is almost certain that when a Particular Cell will reach upto stage of Ageing
Wear & Tear Theory
Running Notes
- Grow Older
- Blah Blah
Dictation
With Age, older cells loose their ability to Repair or Replace the Damaged Components due to Various Internal and External Factors, including mutations, Nutrition, Life Style Etc
Factors Affecting Growth and Development
Genetic Factors
- They Control the Growth & Development in All Stages of Human Development
- Starting from
- Fertilisation of Egg & Sperm to
- Embryonic Development to
- Post Natal Development
- That is throughout the Life Cycle of an Individual
- Different Characters Appear at Different Stages of Growth and are controlled by Genes , so to achieve a Co Ordinated Growth Different Genes are needed to be Activated at Specific Time Periods of Life Cycle
Environmental Factors
- Climatic Factors
- Eskimos - Polar Region
- Less Rate of Growth & Development
- Negrito - Africa Region
- Faster Rate of Growth and Development
- Migration of Individuals and Exposure to New Geographical Conditions can alter the Rate of Growth and Development
Socio Economic + Cultural Factors
- Availability of
- Food & Nourishment
- Type of Food
- Will detrmine G&D
- Cultural Factors
- In Cultural Factors the
- Home and Hygiene of the Local Community
- Acceptance & Non Acceptance to Intoxicants
- Practises of Polygamy
- Frequent Pregnancies
- Will Alter Rate of Growth & Development
- In Mothers, Foetus & Kids
Biochemical Factors
Running Notes
- Hormones - Most Important Here
- G&D is Interplay of Functioning of Hormones
- Balance of Hormones Needed in 3 Stages
- Pre Natal
- HCG
- Human Chorionic Gonadotrophin
- Released by Placenta
- Thyroxine
- Post atal
- Thyroxine
- Growth Hormones
- Adolescence
- Thyroxine _ Growth Hormone
- LH - Lutinising Hormone
- Released By : Anterior Pituitary
- Different Functioning in Males and Females
- Males
- Secretion of Testosterone
- Trigger Growth & Development
- Females
- Helps in Ovulation → Menstrual Maturity
- Trigger Growth & Development
- FSH - Follicle Stimulating Hormone
- Stimulates Release of Egg in Females
Dictation
Entire Process of Human Growth & Development in
Pre Natal
Post Natal
Adolescence
is largely a Result of an Interplay between various Hormones playing a Crucial Role in G&D
In Pre Natal G&D
Two Most Important Hormones are : Thyroxine & HCG
HCG
Human Chorionic Gonadotrophin
Released by Placenta
In Post Natal G&D
Two Most Important Hormones are : Thyroxine & Growth Hormone
Thyroxine - by Thyroid Gland
Growth Hormone - by Pituitary Gland
In Adolescent Stages : Thyroxine & Growth Hormones are accompanied by LH & SFH
LH in Males & Females
Luteinising Hormone - Released by Pituitary Gland
Responsible for
Females - Ovulation
Males - Secretion fo Testosterones in
Helps in Development of Secondary Sexual Characters in Males & Females
FSH in Females
Follicle Stimulating Hormones - Released by Pituitary Gland
Responsible for
Secondary Sexual Characters
Secretion of Estrogen
Nutritional Factors
Nutritional Requirements of Individuals may vary based on the
Genetic Factors
Environmental Factors
Physical Activity etc
It is also Variable in Males and Females
Hence, If Nutritional Requirement are not Fulfilled Growth & Development will not be optimal
i.e Malnourishment can lead to
Impairment in Growth
Delayed Growth
Stunting Etc
Other Factors
Secular Trends in Human Growth
Background
Related only to Growth & Not Development
Direction in Which Growth is Going is Secular Trend
Its Uni Directional, cannot be Cyclic or Reversed
Its Uni Directional and Consistent
Types of Secular Trends
Positive
in a Specified Direction
Body Size & Weight Increase
Negative
Reduction in Size Generations after Generations
Age of Maturation Decrease
Neutral
Cession of Trend
Case Studies
R M Malina
Secular Trends in Height of Adults
11 19 Century Negative Secular Trend
After Mid 19th Century - Trend Reversed
A S Rosh
- Based on Children
- Height of Children at Each Age is showing Positive Secular Trend
- Factors : Better Health & Nutrition
Definition
Secular Trend in Human Growth : means Growth Trends on Physical Parameters of Human Body like Height and Weight which follow a Specified Direction and remain consistent over time.
Displayed By Maximum Population and Age Groups.
These Trends are not cyclical or seasonal.
Based on Longitudinal Growth Studies in Different Human Groups from Mid 19th Century, a Secular Trend of Growth has been observed by Anthropologists as well as by nutritionists